![]() DHRs are clinically classified as immediate reactions (IRs) (appearing 1-6 hours after drug intake) or nonimmediate reactions (NIRs) (appearing >1 hour after drug intake). The term "drug allergy" refers to a specific immunologically mediated drug hypersensitivity reaction (DHRs). It is a type of unpredictable ADR and includes reactions induced by immune or inflammatory cells as well as other non-immunological mechanisms. The term "drug hypersensitivity" refers to objectively reproducible symptoms or signs initiated by exposure to a drug at a dose normally tolerated by non-hypersensitive persons. While knowledge of ADEs is important in efforts to improve patient safety, ADRs are the primary focus of regulatory agencies and post-marketing surveillance. ADEs extend beyond ADRs to include harm related to medication errors and drug/food interactions. ![]() ![]() Head of Unit of Allergic Diseases, Malaga Regional University HospitalĬoordinator of the Spanish Allergy Network ARADyALįull Professor of Medicine, Malaga UniversityĪdverse drug reactions (ADRs) are broadly divided into predictable (related to pharmacologic actions of the drug in otherwise normal individuals) and unpredictable reactions (related to individual’s immunological response and, on occasion, to genetic differences in susceptible patients).ĪDRs should be differentiated from adverse drug events (ADEs). Home: Education and Programs: Education: Allergic Disease Resource Center: Professionals: Drug Allergies Drug Allergiesīernard Thong MBBS, MRCP (UK), FRCP (Edin), FAAAAI ![]()
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